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Hepatocellular carcinoma: Is there a potential for chemoprevention using cyclooxygenase‐2 inhibitors?
Author(s) -
Koga Hironori
Publication year - 2003
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.11576
Subject(s) - cyclooxygenase , medicine , in vivo , cancer research , hepatocellular carcinoma , pharmacology , enzyme , biology , biochemistry , microbiology and biotechnology
Inhibitors of cyclooxygenase‐2 (COX‐2) have proapoptotic and antiangiogenic effects on malignant tumors and inhibit their invasion to surrounding tissues. These properties are derived from COX‐dependent and/or COX‐independent signaling via peroxisome proliferator‐activated receptor γ. Although the role of COX‐2 involvement in human hepatocarcinogenesis has not been determined yet, selective COX‐2 inhibitors with COX‐independent properties may potentially suppress hepatocarcinogenesis. This hypothesis should be confirmed in in vivo studies using animal models. These studies may provide insights into any application of the COX‐2 inhibitor for primary and/or secondary chemoprevention. Cancer 2003;98:661–7. © 2003 American Cancer Society. DOI 10.1002/cncr.11576