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Overview of bladder cancer trials in the Cancer and Leukemia Group B
Author(s) -
Small Eric J.,
Halabi Susan,
Dalbagni Guido,
Pruthi Raj,
Phillips George,
Edelman Martin,
Bajorin Dean
Publication year - 2003
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.11299
Subject(s) - medicine , gemcitabine , oncology , regimen , bladder cancer , carboplatin , cystectomy , cancer , chemotherapy , surgery , cisplatin
Abstract The Cancer and Leukemia Group B (CALGB) Genitourinary Committee has developed a broad range of clinical trials across most stages of bladder cancer. Recurrence rates of superficial bladder cancer after transurethral resection range from 50–70%. Although adjuvant bacillus Calmette–Guerin reduces the risk of disease recurrence or progression, only 30% of patients have long‐term disease‐free survival. Because the development of novel secondline agents is needed, the CALGB is evaluating the utility of intravesicle gemcitabine as well as an oral proapoptotic agent (CP‐461). In patients with locally advanced disease with an increased risk of disease recurrence after cystectomy, a randomized trial of conventional chemotherapy versus sequential dose‐dense therapy is under development. The gemcitabine/cisplatin combination has become a commonly used regimen for the treatment of advanced transitional cell carcinoma (TCC). The CALGB is undertaking a Phase II study that incorporates a fixed dose rate gemcitabine infusion in this regimen, together with a selective epidermal growth factor receptor tyrosine kinase inhibitor, Iressa (Astra Zeneca, Wilmington, DE). In patients with renal insufficiency, a regimen of carboplatin, gemcitabine, and Iressa is planned. Novel agents, including arsenic trioxide and trastuzumab (Herceptin; Genentech, Inc., South San Francisco, CA), are being evaluated as secondline therapy in patients with advanced TCC who have disease progression after frontline therapy. Cancer 2003;97(8 Suppl):2090–8. © 2003 American Cancer Society. DOI 10.1002/cncr.11299