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Correlation between HER‐2 expression and response to neoadjuvant chemotherapy with 5‐fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma
Author(s) -
Zhang Fan,
Yang Ying,
Smith Terry,
Kau ShuWan,
McConathy Judy M.,
Esteva Francisco J.,
Kuerer Henry M.,
Symmans W. Fraser,
Buzdar Aman U.,
Hortobagyi Gabriel N.,
Pusztai Lajos
Publication year - 2003
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.11245
Subject(s) - medicine , concordance , cyclophosphamide , breast cancer , breast carcinoma , chemotherapy , lymph node , stage (stratigraphy) , oncology , neoadjuvant therapy , fluorouracil , pathology , radiology , cancer , paleontology , biology
BACKGROUND The objective of this study was to determine whether HER‐2 overexpression is associated with improved response to neoadjuvant chemotherapy with 5‐fluorouracil, doxorubicin, cyclophosphamide (FAC) in patients with breast carcinoma. METHODS Ninety‐seven patients with Stage I–III breast carcinoma were included. HER‐2 expression was determined by routine clinical laboratory assessment, and tumors with 3 + immunohistochemistry staining intensity or gene amplification by fluorescent in situ hybridization were considered HER‐2 positive. Response was assessed by physical examination, imaging assessment, and pathologic assessment at the time of surgery. RESULTS The median patient age was 45 years. At baseline, 68% of patients had lymph node positive disease, 87% had ≥ T2 tumors, and 28% of patients had HER‐2 positive tumors. Eighty‐four percent of patients received four courses of FAC, 8% of patients received 3 courses of FAC, and the remaining 8% of patients received 5–6 courses of FAC. The clinical response rate (complete response [CR] and partial response [PR]) was 78%, the imaging response rate (CR and PR) was 64%, and 15% of patients had a good pathologic response, defined as a CR or minimal residual disease (tumor measuring < 1 cm in greatest dimension and negative lymph nodes). Concordance between the three methods of response assessment (clinical, pathologic, and imaging) was modest and was best between clinical assessment and imaging assessment (64% concordance). HER‐2 status did not correlate with pathologic or clinical response (assessed by physical examination or imaging), although a nonsignificant trend was noted toward better response in patients with breast tumors that overexpressed HER‐2. CONCLUSIONS The authors found no significant correlation between HER‐2 expression and clinical or pathologic response to neoadjuvant chemotherapy in patients with breast carcinoma. Cancer 2003;97:1758–65. © 2003 American Cancer Society. DOI 10.1002/cncr.11245