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Clinical and survival covariates of eight classes of childhood supratentorial neuroglial tumors
Author(s) -
Gilles Floyd H.,
Leviton Alan,
Tavaré C. Jane,
Adelman Lester,
Rorke Lucy B.,
Sobel Eugene L.,
HedleyWhyte E. Tessa,
Davis Richard L.
Publication year - 2002
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.10815
Subject(s) - covariate , medicine , survival analysis , proportional hazards model , overall survival , survival rate , glioblastoma , oncology , pathology , cancer research , statistics , mathematics
BACKGROUND In the current study, the authors investigated clinical, surgical, and histologic characteristics (covariates) and their interactions in eight previously identified classes of childhood supratentorial neuroglial tumors. The classes resulted from 5 factor score profiles on 703 supratentorial neuroglial tumors in the Childhood Brain Tumor Consortium database. METHODS The Cox proportional models were used to identify class survival covariates. RESULTS Age was found to be a survival covariate only in Class 1, in which older age increased the 5‐year survival rate 73% from the first year (0.49) to the tenth year (0.85). A greater amount of tumor removed improved survival in Classes 2 and 4 only. Rosenthal fibers improved survival in Class 2 and overrode the negative effects of high Proliferative factor scores and pleomorphic nuclei. Survival for Class 3 children with high Proliferative factor scores improved from 0.60 to 0.95 as the Spongy factor scores increased. Survival in Class 4 increased from 0.17 to 0.39 with total tumor removal. Irregular nuclei and glomeruloid capillaries improved survival in Class 5 patients. Class 6 survival improved with low cell density. Macrocysts in tumors in Classes 1 and 5 were found to improve survival. CONCLUSIONS As a result of the current study, the authors conclude that survival covariates differ with tumor class and may modify prognosis considerably. Cancer 2002;95:1302–10. © 2002 American Cancer Society. DOI 10.1002/cncr.10815