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Detection method and breast carcinoma histology
Author(s) -
Newcomer Laura M.,
Newcomb Polly A.,
TrenthamDietz Amy,
Storer Barry E.,
Yasui Yutaka,
Daling Janet R.,
Potter John D.
Publication year - 2002
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.10695
Subject(s) - medicine , invasive lobular carcinoma , carcinoma , ductal carcinoma , histopathology , breast cancer , lobular carcinoma , mammography , medullary carcinoma , medullary cavity , adenocarcinoma , mucinous carcinoma , cancer , population , breast carcinoma , pathology , oncology , thyroid carcinoma , invasive ductal carcinoma , thyroid , environmental health
BACKGROUND The association between method of detection and breast carcinoma histopathology has not been assessed adequately in a population‐based setting. METHODS Among women who were included in a population‐based, case‐control study of breast cancer, patients who were newly diagnosed with invasive breast carcinoma were identified from Wisconsin's statewide tumor registry. Only women age ≥ 50 years were analyzed, because screening by mammography was not recommended before age 50 years at the time of the study. The breast tumors among these women ( n = 2341 tumors) included the following histopathologies: lobular carcinoma ( n = 206 tumors); ductal carcinoma, not otherwise specified ( n = 1920 tumors); papillary carcinoma ( n = 15 tumors); medullary carcinoma ( n = 36 tumors); mucinous adenocarcinoma ( n = 56 tumors); tubular adenocarcinoma ( n = 41 tumors); invasive comedocarcinoma ( n = 24 tumors); scirrhous adenocarcinoma ( n = 15 tumors); and mixed ductal/lobular carcinoma ( n = 28 tumors). RESULTS Overall, women reported that 41% of tumors were detected by mammography, 48% of tumors were self detected, and 11% of tumors were detected by clinical breast examination (CBE). Detection by mammography was significantly more likely for women who had tubular carcinoma (83%; P < 0.001) and invasive comedocarcinoma (67%; P = 0.23) compared with women who had ductal carcinoma (40%). Mammography was significantly less likely to detect medullary carcinoma (17%) than ductal carcinoma (40%; P = 0.01). Lobular carcinoma was the only histopathology that, compared with ductal carcinoma, was detected significantly more often by CBE than by self detection. Mammography detected lobular carcinoma (42%) as frequently as ductal carcinoma (40%). However, the use of postmenopausal hormones may have modified these detection patterns: Among current users, mammography discovered a greater percentage of ductal carcinomas (51%) and fewer lobular carcinomas (36%) than nonusers. CONCLUSIONS Among women age ≥ 50 years, breast cancer detection by mammography, self detection, and CBE varied according to tumor histopathology. Cancer 2002;95:470–7. © 2002 American Cancer Society. DOI 10.1002/cncr.10695