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Imprint cytologic features of pulmonary sclerosing hemangioma
Author(s) -
Iyoda Akira,
Baba Masayuki,
Saitoh Hiroko,
Hoshino Hidehisa,
Shibuya Kiyoshi,
Nomoto Yasushi,
Horiuchi Fumio,
Hiroshima Kenzo,
Ohwada Hidemi,
Fujisawa Takehiko
Publication year - 2002
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.10616
Subject(s) - pathology , hemangioma , medicine , histogenesis , adenocarcinoma , cytology , papillary adenocarcinoma , cancer , immunohistochemistry
Abstract BACKGROUND Sclerosing hemangiomas (SH) of the lung are uncommon tumors and are thought to be benign. However, histogenesis of these tumors has not yet been characterized adequately. Moreover, there are few reports dealing with their cytologic features, and it is generally considered difficult to make accurate diagnoses of sclerosing hemangiomas that have a predominantly papillary pattern. METHODS Cytologic features were analyzed for 15 sclerosing hemangiomas, and cytologic features of sclerosing hemangioma were compared with features of 22 cases of well‐differentiated papillary adenocarcinoma classified as pathologic Stage 1A. RESULTS Blood and round cells were observed more frequently in SH than in adenocarcinomas ( P < 0.05), whereas necrosis was seen more frequently in adenocarcinomas than in SH ( P < 0.05). The presence of nucleoli, nuclear indentations, irregularities of nuclear margins, nuclear polymorphisms, and high nuclear‐cytoplasmic (NC) ratios of tumor cells were observed less frequently in SH. Polynuclear (having three or more nuclei) tumor cells were observed only in adenocarcinoma cases. In morphometric studies, the nuclear areas, cytoplasmic areas, NC ratios, long axes of nuclei, short axes of nuclei, and nuclear rotundity ratios were significantly higher in adenocarcinoma cells than in SH cells ( P < 0.05). CONCLUSIONS The presence of polymorphous cells and tumor cells with bland nuclei are characteristic cytologic findings associated with sclerosing hemangioma. It is possible to make accurate diagnoses for SH cases preoperatively by careful cytologic characterization. Cancer (Cancer Cytopathol) 2002. © 2002 American Cancer Society.