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Survival analysis with p27 expression and apoptosis appears to estimate the prognosis of patients with synovial sarcoma more accurately
Author(s) -
Kawauchi Shigeto,
Goto Yoshinari,
Ihara Koichiro,
Furuya Tomoko,
Oga Atsunori,
Tsuneyoshi Masazumi,
Kawai Shinya,
Sasaki Kohsuke
Publication year - 2002
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.10556
Subject(s) - synovial sarcoma , apoptosis , medicine , sarcoma , cancer , cancer research , immunohistochemistry , multivariate analysis , pathology , oncology , biology , biochemistry
BACKGROUND Although recent experimental studies have implicated p27 as a regulator of apoptosis in a number of neoplasms, to the authors' knowledge the relation between p27 expression and apoptosis has not yet been established in synovial sarcoma. METHODS The relation between p27, apoptosis, and clinicopathologic features were examined in 62 synovial sarcoma cases. RESULTS p27 expression was found to be correlated inversely with the extent of apoptosis in synovial sarcomas. On survival analysis, p27 expression was found to be a significant and independent prognostic factor. Although the extent of apoptosis was determined to be prognostically significant, it failed to retain an independent and significant value on multivariate analysis. The combination of p27 expression and apoptosis allowed for the more accurate estimation of prognosis in patients with synovial sarcoma than either parameter alone. CONCLUSIONS A combination of p27 expression and extent of apoptosis permitted the more accurate estimation ofy the prognosis of patients with synovial sarcoma. Cancer 2002; 94:2712–8. © 2002 American Cancer Society. DOI 10.1002/cncr.10556