Premium
Transcervical needle biopsy for the differential diagnosis between uterine sarcoma and leiomyoma
Author(s) -
Kawamura Naoki,
Ichimura Tomoyuki,
Ito Fumihiro,
Shibata Sachiko,
Takahashi Kumiyo,
Tsujimura Akemi,
Ishiko Osamu,
Haba Tomoko,
Wakasa Kenichi,
Ogita Sachio
Publication year - 2002
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.10382
Subject(s) - medicine , leiomyoma , biopsy , myoma , leiomyosarcoma , radiology , differential diagnosis , sarcoma , malignancy , uterine sarcoma , magnetic resonance imaging , uterus , pathology
BACKGROUND The clinical differential diagnosis between uterine sarcoma and benign leiomyoma is difficult even with magnetic resonance imaging (MRI). Therefore, a considerable number of patients have undergone hysterectomies due to an indication of “suspected malignancy” based on tumor size alone. However, approximately 80% of these hysterectomies have been judged to have been recommended inappropriately. In such situations, reliable preoperative diagnostic tests are required. The authors have evaluated the accuracy of needle biopsy for uterine myoma‐like tumors, a procedure that to the authors' knowledge has been performed infrequently. METHODS Transcervical needle biopsy was performed in 435 patients with uterine myoma‐like tumors. The biopsy specimens were scored for degree of malignancy according to the histopathologic criteria proposed by Bell et al. Histopathologic evaluation of surgical specimens and clinical outcome after 2 years of follow‐up were used as the reference standards. RESULTS Of 435 patients, 7 had uterine sarcomas, 4 of which were scored as ≥ 4 points and were diagnosed as “sarcoma” by needle biopsy alone. No sarcoma cases were included in the group of patients with a score of 0. The cutoff score combining the highest sensitivity and specificity with respect to distinguishing uterine leiomyosarcoma from uterine leiomyoma was 2; sensitivity, specificity, and positive and negative predictive values were 100%, 98.6%, 58%, and 100.0%, respectively. CONCLUSIONS Transcervical needle biopsy using histopathologic scoring is a reliable diagnostic test for the differential diagnosis between uterine sarcoma and leiomyoma. This diagnostic method, combined with MRI screening, could reduce the number of patients currently undergoing unnecessary surgery. Cancer 2002;94:1713–20. © 2002 American Cancer Society. DOI 10.1002/cncr.10382