Diagnostic utility of Glut-1 and CA 15-3 in discriminating adenocarcinoma from hepatocellular carcinoma in liver tumors biopsied by fine-needle aspiration | Zendy

R.L. Zimmerman | Zendy; Melissa Burke | Zendy; Nancy A. Young | Zendy; Charalambos Solomides | Zendy; Marluce Bibbo | Zendy

Open Access

Diagnostic utility of Glut-1 and CA 15-3 in discriminating adenocarcinoma from hepatocellular carcinoma in liver tumors biopsied by fine-needle aspiration

Author(s) -

R.L. Zimmerman,

Melissa Burke,

Nancy A. Young,

Charalambos Solomides,

Marluce Bibbo

Publication year - 2002

Publication title -

cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.052

H-Index - 304

eISSN - 1045-7410

pISSN - 0008-543X

DOI - 10.1002/cncr.10309.abs

Subject(s) - medicine , hepatocellular carcinoma , pathology , malignancy , carcinoembryonic antigen , carcinoma , adenocarcinoma , fine needle aspiration , immunohistochemistry , biopsy , staining , immunostaining , cancer

Diagnosing liver tumors can be difficult in the setting of a poorly differentiated tumor or tumors with no known prior malignancy. Frequently, alpha-fetoprotein, carcinoembryonic antigen, factor VIII, and mucicarmine have been employed to distinguish hepatocellular carcinoma (HCC) from adenocarcinoma. However, these stains have their limitations. CA 15-3 and Glut-1 are expressed in a variety of carcinomas. To the authors' knowledge, their expression in HCC has not been studied extensively. The authors examined the clinical utility of CA 15-3 and Glut-1 in the setting of fine-needle aspiration biopsy samples from the liver.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research