Premium
Clinical significance of plasma endostatin in acute myeloid leukemia/myelodysplastic syndrome
Author(s) -
Lai Raymond,
Estey Elihu,
Shen Yu,
Despa Simona,
Kantarjian Hagop,
Beran Miloslav,
Maushouri Taghi,
Quackenbuch Robert C.,
Keating Micheal,
Albitar Maher
Publication year - 2001
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.10200
Subject(s) - medicine , endostatin , myelodysplastic syndromes , myeloid leukemia , gastroenterology , clinical significance , oncology , multivariate analysis , leukemia , immunology , angiogenesis , bone marrow
BACKGROUND Endostatin, a C‐terminal fragment of collagen XVIII, is an endogenous angiogenesis inhibitor. While endostatin is being investigated for its usefulness in treating solid tumors, its significance in hematologic malignancies is unknown. METHODS The authors evaluated plasma endostatin (PE) levels using an enzyme linked immunoassay in 71 patients with acute myeloid leukemia (AML) and 43 patients with myelodysplastic syndrome (MDS), and correlated PE with various clinical parameters. RESULTS There was no significant difference in the median PE level between AML/MDS patients and the normal controls. Nevertheless, patients who achieved complete remission (CR) had a significantly lower median PE level compared to those who did not. In multivariate analysis, PE was found to be a significant ( P = 0.03) predictor of overall survival (OS) with adjustment of the other baseline covariates, including patient age, history of antecedent hematologic disorders, and the use of protective environments. The prognostic value of PE was also evaluated by dividing MDS/AML patients into high and low PE groups using the median PE level of normal controls as the cut‐off. The authors found that patients in the high PE group survived for a significantly shorter time than those patients in the low PE group. CONCLUSIONS PE is a useful prognostic predictor of CR and OS for AML/MDS patients. The mechanism underlying the association between high PE and poor clinical outcome is unclear, although it may be related to the possible PE reflection of tumor burden. Cancer 2002;94:14–7. © 2002 American Cancer Society.