Open AccessMechanosynthesis of Eutectics of Anti‐Inflammatory Drug Ethenzamide – A Comparison with Analogous Cocrystals
Author(s) -
Rajbongshi Trishna,
Kumar Sarmah Kashyap,
Ganduri Ramesh,
Cherukuvada Suryanarayan,
Arhangelskis Mihails,
Thakuria Ranjit
Publication year - 2021
Publication title -
chemistry ‐ methods
Language(s) - English
Resource type - Journals
ISSN - 2628-9725
DOI - 10.1002/cmtd.202100016
Subject(s) - eutectic system , drug , synthon , tetrazole , chemistry , mechanosynthesis , cocrystal , stereochemistry , combinatorial chemistry , pharmacology , materials science , organic chemistry , medicine , hydrogen bond , alloy , composite material , molecule , ball mill
Mechanochemical milling of ethenzamide (ETZ), a nonsteroidal anti‐inflammatory drug, with substituted aromatic carboxylic acids as well as anti‐tuberculosis drug pyrazinamide (PZA) resulted in the formation of eutectics. Although a large number of cocrystals as well as polymorphic cocrystals are reported for ETZ, for the first time we have synthesized six eutectics including an instance of a drug‐drug eutectic system. Supramolecular synthon energy calculations validate the formation of eutectic mixtures over cocrystals with coformers considered in our study.