Open AccessObtaining Kinetics From Continuous Processes: Sampling Multiple Time Points Concurrently With a Single Valve Rotation
Author(s) -
Morin Mathieu A.,
Mallik Debasis,
Zhang Wenyao,
Pietro William,
Manthorpe Jeffrey M.,
Organ Michael G.
Publication year - 2021
Publication title -
chemistry ‐ methods
Language(s) - English
Resource type - Journals
ISSN - 2628-9725
DOI - 10.1002/cmtd.202100003
Subject(s) - sample (material) , process engineering , continuous flow , rotation (mathematics) , trace (psycholinguistics) , process (computing) , flow (mathematics) , computer science , production (economics) , fine chemical , flow chemistry , biochemical engineering , chemistry , engineering , mechanics , raw material , economics , chromatography , physics , artificial intelligence , linguistics , philosophy , organic chemistry , macroeconomics , operating system
The manufacturers of fine chemicals and pharmaceuticals are beginning to accept flow chemistry as a production alternative following the lead of commodity chemical manufacturers, who have been producing goods in continuous format for decades. The ability to trace time backwards by retracting the spatial length of a flow reactor is perhaps one of the biggest advantages of flowed synthesis. However, in the absence of an appropriate tool that would allow scientists to sample throughout the entire space of a production line, the theory is not possible to put into practice. A step in this direction has been taken with the invention of a unique, multi‐port valve/flow reactor that allows the chemist to simultaneously sample multiple timepoints of a chemical transformation with one single valve actuation, thereby capturing instantaneously the entire reaction course of the flowed chemical process.