Open AccessMagnetic resonance spectroscopy (MRS) and its application in Alzheimer's disease
Author(s) -
Mandal Pravat K.
Publication year - 2007
Publication title -
concepts in magnetic resonance part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.229
H-Index - 49
eISSN - 1552-5023
pISSN - 1546-6086
DOI - 10.1002/cmr.a.20072
Subject(s) - magnetic resonance imaging , nuclear magnetic resonance , disease , nuclear magnetic resonance spectroscopy , in vivo magnetic resonance spectroscopy , living systems , human disease , neuroscience , medicine , pathology , computer science , psychology , radiology , physics , artificial intelligence
Magnetic resonance spectroscopy (MRS) is a noninvasive tool to measure the chemical composition of tissues (in vivo) and characterize functional metabolic processes in different parts of the human organs. It provides vital biological information at the molecular level. Combined with magnetic resonance imaging (MRI), an integrated MRI/MRS examination provides anatomical structure, pathological function, and biochemical information about a living system. MRS provides a link between the biochemical alterations and the pathophysiology of disease. This article provides a comprehensive description of the MRS technique and its application in Alzheimer's disease (AD) research. This review is a primer for students and researchers seeking a firm theoretical understanding of MRS physics as well as its application in clinical AD research. © 2007 Wiley Periodicals, Inc. Concepts Magn Reson Part A 30A: 40–64, 2007.