Open AccessImaging efficiency of an X‐ray contrast agent‐incorporated polymeric microparticle
Author(s) -
Ahn Sungsook,
Jung Sung Yong,
Lee Jin Pyung,
Lee Sang Joon
Publication year - 2011
Publication title -
contrast media & molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.714
H-Index - 50
eISSN - 1555-4317
pISSN - 1555-4309
DOI - 10.1002/cmmi.440
Subject(s) - microparticle , synchrotron , polyvinyl alcohol , tracer , materials science , absorption (acoustics) , biocompatible material , x ray , nanotechnology , chemical engineering , chemistry , biomedical engineering , optics , composite material , medicine , physics , nuclear physics , engineering
Biocompatible polymeric encapsulants have been widely used as a delivery vehicle for a variety of drugs and imaging agents. In this study, X‐ray contrast agent (iopamidol) is encapsulated into a polymeric microparticle (polyvinyl alcohol) as a particulate flow tracer in synchrotron X‐ray imaging system. The physical properties of the designed microparticles are investigated and correlated with enhancement in the imaging efficiency by experimental observation and theoretical interpretation. The X‐ray absorption ability of the designed microparticle is assessed by Beer–Lambert–Bouguer law. Particle size, either in dried state or in solvent, primarily dominates the X‐ray absorption ability under the given condition, thus affecting imaging efficiency of the designed X‐ray contrast flow tracers. Copyright © 2011 John Wiley & Sons, Ltd.