Open AccessHow to design 13 C para ‐hydrogen‐induced polarization experiments for MRI applications
Author(s) -
Reineri Francesca,
Viale Alessandra,
Dastrù Walter,
Gobetto Roberto,
Aime Silvio
Publication year - 2010
Publication title -
contrast media & molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.714
H-Index - 50
eISSN - 1555-4317
pISSN - 1555-4309
DOI - 10.1002/cmmi.407
Subject(s) - spin isomers of hydrogen , hyperpolarization (physics) , heteronuclear molecule , polarization (electrochemistry) , induced polarization , nuclear magnetic resonance , chemistry , computer science , hydrogen , materials science , nuclear magnetic resonance spectroscopy , physics , organic chemistry , quantum mechanics , electrical resistivity and conductivity
The application of hyperpolarization techniques for MRI purposes is gathering increasing attention, especially for nuclei such as 13 C or 129 Xe. Among the different proposed methods, ParaHydrogen Induced Polarization requires relatively cheap equipment. The setup of an MRI experiment by means of parahydrogen requires the application of skills and methodologies that derive from different fields of knowledge. The basic theory and a practical insight of this method are presented here. Parahydrogenation of alkynes, having a labelled 13 CO group adjacent to the triple bond, catalyzed by Rh(I) complexes containing a chelating phosphine, represents the best choice for producing and maintaining high heteronuclear polarization effect. In order to transform anti‐phase into in‐phase (net) 13 C polarization for MRI application it is necessary to set up the described magnetic field cycle procedure. In vitro and in vivo images have been acquired using fast imaging sequences (RARE and trueFISP). Copyright © 2010 John Wiley & Sons, Ltd.