Open AccessDeveloping imidazoles as CEST MRI pH sensors
Author(s) -
Yang Xing,
Song Xiaolei,
Ray Banerjee Sangeeta,
Li Yuguo,
Byun Youngjoo,
Liu Guanshu,
Bhujwalla Zaver M.,
Pomper Martin G.,
McMahon Michael T.
Publication year - 2016
Publication title -
contrast media & molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.714
H-Index - 50
eISSN - 1555-4317
pISSN - 1555-4309
DOI - 10.1002/cmmi.1693
Subject(s) - imidazole , chemistry , magnetic resonance imaging , nuclear magnetic resonance , in vivo , contrast (vision) , gadolinium , radiology , stereochemistry , organic chemistry , medicine , physics , microbiology and biotechnology , artificial intelligence , biology , computer science
A series of intra‐molecular hydrogen bonded imidazoles and related heterocyclic compounds were screened for their N–H chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) contrast properties. Of the compounds, imidazole‐4,5‐dicarboxamides (I45DCs) were found to provide the strongest contrast, with the contrast produced at a large chemical shift from water (7.8 ppm) and strongly dependent on pH. We have tested several probes based on this scaffold, and demonstrated that these probes could be applied for in vivo detection of kidney pH after intravenous administration. Copyright © 2016 John Wiley & Sons, Ltd.