Open AccessUltrasmall particles for Gd‐MRI and 68 Ga‐PET dual imaging
Author(s) -
Truillet Charles,
Bouziotis Penelope,
Tsoukalas Charalambos,
Brugière Jérémy,
Martini Matteo,
Sancey Lucie,
Brichart Thomas,
Denat Franck,
Boschetti Frédéric,
Darbost Ulrich,
Bonnamour Isabelle,
Stellas Dimitris,
Anagnostopoulos Constantinos D.,
Koutoulidis Vassilis,
Moulopoulos Lia A.,
Perriat Pascal,
Lux François,
Tillement Olivier
Publication year - 2014
Publication title -
contrast media & molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.714
H-Index - 50
eISSN - 1555-4317
pISSN - 1555-4309
DOI - 10.1002/cmmi.1633
Subject(s) - positron emission tomography , magnetic resonance imaging , nanoparticle , chemistry , pet imaging , nuclear medicine , radiochemistry , molecular imaging , imaging agent , nuclear magnetic resonance , materials science , nuclear chemistry , nanotechnology , in vivo , physics , medicine , radiology , microbiology and biotechnology , biology
Nanoparticles made of a polysiloxane matrix and surrounded by 1,4,7,10‐tetraazacyclododecane‐1‐glutaric anhydride‐4,7,10‐triacetic acid (DOTAGA)[Gd 3+ ] and 2,2'‐(7‐(1‐carboxy‐4‐((2,5‐dioxopyrrolidin‐1‐yl)oxy)‐4‐oxobutyl)‐1,4,7‐triazonane‐1,4‐diyl)diacetic acid) NODAGA[ 68 Ga 3+ ] have been synthesized for positron emission tomography/magnetic resonance (PET/MRI) dual imaging. Characterizations were carried out in order to determine the nature of the ligands available for radiolabelling and to quantify them. High radiolabelling purity (>95%) after 68 Ga labelling was obtained. The MR and PET images demonstrate the possibility of using the nanoparticles for a combined PET/MR imaging scanner. The images show fast renal elimination of the nanoparticles after intravenous injection.Copyright © 2014 John Wiley & Sons, Ltd.