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Front Cover: The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition (ChemMedChem 19/2022)
Author(s) -
Furet Pascal,
Bordas Vincent,
Le Douget Mickaël,
Salem Bahaa,
Mesrouze Yannick,
ImbachWeese Patricia,
Sellner Holger,
Voegtle Markus,
Soldermann Nicolas,
Chapeau Emilie,
Wartmann Markus,
Scheufler Clemens,
Fernandez Cesar,
Kallen Joerg,
Guagnano Vito,
Chène Patrick,
Schmelzle Tobias
Publication year - 2022
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202200514
Subject(s) - front cover , chemistry , small molecule , cover (algebra) , molecule , class (philosophy) , stereochemistry , pascal (unit) , physics , biochemistry , computer science , engineering , mechanical engineering , organic chemistry , quantum mechanics , artificial intelligence
The Front Cover shows a representative of the first class of potent disrupters of the YAP‐TEAD interaction in complex with TEAD. This molecule inhibits the transcriptional activity of TEAD, leading to a robust cellular antiproliferative effect. More information can be found in the Research Article by Pascal Furet, Vito Guagnano, Patrick Chène, Tobias Schmelzle, et al.