Premium
Front Cover: Tailoring Additively Manufactured Titanium Implants for Short‐Time Pediatric Implantations with Enhanced Bactericidal Activity (ChemMedChem 2/2022)
Author(s) -
Maher Shaheer,
Linklater Denver,
Rastin Hadi,
Le Yap Pei,
Ivanova Elena P.,
Losic Dusan
Publication year - 2022
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202100781
Subject(s) - titanium , anodizing , materials science , antibacterial activity , titanium alloy , gallium , surface modification , nanotechnology , alloy , chemistry , biomedical engineering , metallurgy , bacteria , medicine , aluminium , biology , genetics
The Front Cover illustrates fabricated 3D‐printed titanium alloy model implants modified by electrochemical anodization to generate vertically aligned titania nanotubes (TNTs) on the surface with specific diameters (∼100 nm) aiming to reduce bone cell attachment and proliferation. To achieve enhanced antibacterial performance, the nanotubes were loaded with gallium nitrate as antibacterial agent. The physicochemical characteristics of these implants confirmed their ability to reduce osteoblast cell MG‐63 cells prefiltration and overgrowth and strong antibacterial activity against S. aureus and P. aeruginosa with supressed bacterial attachment and high rates of bacterial death. The engineering of theses temporary Ti implants with enhanced bactericidal properties with reduced bone cell attachment is proposed as new strategy for designing of short‐term implants in paediatrics. Cover design by Raymediasa. More information can be found in the Full Paper by Shaheer Maher, Dusan Losic et al.