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Front Cover: Synthesis of L‐[5‐ 11 C]Leucine and L‐α‐[5‐ 11 C]Methylleucine via Pd 0 ‐mediated 11 C‐Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging (ChemMedChem 21/2021)
Author(s) -
Takatani Shuhei,
Tahara Tsuyoshi,
Tsuji Mieko,
Ozaki Daiki,
Shibata Nina,
Hashizume Yoshinobu,
Suzuki Masaaki,
Onoe Hirotaka,
Watanabe Yasuyoshi,
Doi Hisashi
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202100672
Subject(s) - front cover , leucine , chemistry , methylation , molecule , radiochemistry , in vivo , cover (algebra) , biochemistry , amino acid , dna , biology , organic chemistry , mechanical engineering , microbiology and biotechnology , engineering
The Front Cover shows a 11 C‐radiolabeling method of leucine molecules and a demonstration of in vivo PET imaging. The 11 C‐incorporation at the 5‐position of leucine was realized by Pd‐mediated rapid reactions of 11 C‐methylation and hydrogenation. According to the mouse PET studies, 11 C‐radiolabeled l ‐α‐methylleucine was confirmed to be a valuable tracer for visualizing tumors. The coming human PET studies of 11 C‐radiolabeled leucine molecules are greatly anticipated. More information can be found in the Full Paper by Hirotaka Onoe, Yasuyoshi Watanabe, Hisashi Doi et al.