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Front Cover: Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity (ChemMedChem 18/2021)
Author(s) -
Sung YuShien,
Wu Wangbin,
Ewbank Megan A.,
Utterback Rachel D.,
Marty Michael T.,
Tomat Elisa
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202100579
Subject(s) - bioconjugation , chemistry , disulfide bond , albumin , conjugate , semicarbazone , front cover , imidazole , cysteine , biochemistry , combinatorial chemistry , stereochemistry , cover (algebra) , enzyme , mechanical engineering , mathematical analysis , mathematics , engineering
The Front Cover shows the bioconjugation of an antiproliferative prochelator to serum albumin via formation of a disulfide bond with a reduced cysteine on the protein. The abundance of albumin in blood is represented by the red background featuring red blood cells. The disulfide‐masked prochelators of this class have antiproliferative activities at submicromolar levels in a panel of cancer cell lines. Cover design by Matthew W. Lluis. More information can be found in the Communication by Elisa Tomat et al..