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Front Cover: Synthesis and Antimicrobial Activity Evaluation of Imidazole‐Fused Imidazo[2,1‐ b ][1,3,4]thiadiazole Analogues (15/2021)
Author(s) -
Yan Guo Fang,
Ji Zheng Chang,
Wang Meiyuan,
Ai Jiangping,
Ying Han Lan,
Yang Liu,
Fang Lu Ye,
Xuan Yang Yu,
Guan Piao Ming,
Piao HuRi,
Jin ChunMei,
Jin Cheng Hua
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202100501
Subject(s) - candida albicans , hemolysis , imidazole , front cover , antifungal , stereochemistry , antimicrobial , chemistry , proteus , antibacterial activity , cover (algebra) , microbiology and biotechnology , bacteria , organic chemistry , biology , escherichia coli , biochemistry , mechanical engineering , genetics , gene , immunology , engineering
The Front Cover represents this study where three series of new imidazole‐fused imidazo[2,1‐ b ][1,3,4]thiadiazole analogues were synthesized and evaluated for their antibacterial and antifungal properties. The blue picture is the 3D structure of the compound 21a which demonstrated the strongest antifungal activity with good safety. The gray images show Candida albicans and present the antifungal activity of the compound. The safety of compound 21a in this study was tested by hemolysis, represented here by the triangular flask used in hemolysis tests and the magnified red blood cells. In the background one can also see structures of compound 21a and the intermediate used. Cover art created by Wen Bo Xu, Fang Yan Guo, Jiangping Ai, Meiyuan Wang, Xu Cheng, and Weifang Yan. More information can be found in the Full Paper by Chun‐Mei Jin, Cheng Hua Jin et al.