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Aliphatic 18 F‐Radiofluorination: Recent Advances in the Labeling of Base‐Sensitive Substrates **
Author(s) -
Bratteby Klas,
Shalgunov Vladimir,
Herth Matthias Manfred
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202100303
Subject(s) - chemistry , pet imaging , base (topology) , nanotechnology , combinatorial chemistry , computer science , materials science , nuclear medicine , positron emission tomography , medicine , mathematics , mathematical analysis
Aliphatic fluorine‐18 radiolabeling is the most commonly used method to synthesize tracers for PET‐imaging. With an increasing demand for 18 F‐radiotracers for clinical applications, new labeling strategies aiming to increase radiochemical yields of established tracers or, more importantly, to enable 18 F‐labeling of new scaffolds have been developed. In recent years, increased attention has been focused on the direct aliphatic 18 F‐fluorination of base‐sensitive substrates in this respect. This minireview gives a concise overview of the recent advances within this field and aims to highlight the advantages and limitations of these methods.