Premium
Chemical Reactions Trigger Peptide Self‐Assembly in vivo for Tumor Therapy
Author(s) -
Zeng XiangZhong,
An HongWei,
Wang Hao
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202100254
Subject(s) - peptide , in vivo , self healing hydrogels , self assembling peptide , nanotechnology , self assembly , biocompatibility , chemistry , biophysics , materials science , biochemistry , biology , organic chemistry , microbiology and biotechnology
Abstract Self‐assembly peptide materials have promoted the development of science research including life science, optics, medicine, and catalysis over the past two decades. Especially in tumor treatment, peptide self‐assembly strategies have exhibited promising potential by their high degree of biocompatibility, construction modularization, and diversity in structure controllability. Driven by physical and chemical triggers, peptides can self‐assemble in vivo to form fibers, spheres, hydrogels, or ribbons to achieve predeterminate biological functions. Peptide self‐assembly triggered by chemical reactions provides superior specificity and intelligent responsiveness to produce assembly‐induced biological effects in target regions. Herein, from the perspective of triggers of peptide assembly, we briefly review the applications of in vivo peptide self‐assembly strategies for tumor treatment, including tumor‐pathology‐factor‐induced chemical reactions and bio‐orthogonal reactions