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A CaO 2 @Tannic Acid‐Fe III Nanoconjugate for Enhanced Chemodynamic Tumor Therapy
Author(s) -
Chen Fei,
Yang Beibei,
Xu Lan,
Yang Jinfeng,
Li Jishan
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202100108
Subject(s) - hydrogen peroxide , tannic acid , chemistry , catalysis , in vivo , cancer cell , limiting , reactive oxygen species , tumor microenvironment , fenton reaction , radical , hydroxyl radical , biochemistry , cancer , cancer research , tumor cells , biology , organic chemistry , mechanical engineering , genetics , microbiology and biotechnology , engineering
Chemodynamic therapy (CDT) is an effective tumor treatment strategy in which Fe II reacts with hydrogen peroxide (H 2 O 2 ) in tumor cells to produce highly toxic hydroxyl radical ( . OH) through the Fenton reaction. However, the content of endogenous H 2 O 2 in cells is limited, and the reaction between Fe III and H 2 O 2 is inefficient, greatly limiting the efficiency of the Fenton reaction and reducing the effectiveness of tumor treatment. Therefore, in this work, we designed and synthesized a new type of nano‐system (CaO 2 @TA‐Fe III ) for the enhanced CDT of tumors, in which the polyphenolic compound‐ tannic acid (TA) and Fe III formed a TA‐Fe nano‐coating on the surface of calcium peroxide (CaO 2 ) nanospherical aggregates. When the CaO 2 @TA‐Fe III nanoconjugates reach the tumor site, the CaO 2 contained in the nanoconjugates produces H 2 O 2 after disintegration in tumor cells, and the carried TA rapidly reduces Fe III to Fe II , solving the two major shortcomings in CDT of (1) insufficient content of H 2 O 2 in cancer cells, and (2) low catalytic efficiency of the Fenton reaction. Additionally, the . OH produced in the Fenton reaction induces oxidative stress for the tumor cells, promoting the occurrence of the “calcium overload” process, and thereby accelerating the death of tumor cells. Experimental results in vitro and in vivo showed that CaO 2 @TA‐Fe III nanoconjugates can effectively kill cancer cells and display an excellent tumor therapeutic effect. We believe that the CaO 2 @TA‐Fe III nanoconjugates are a promising new nano‐platform for highly effective tumor treatment.