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Cover Feature: Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar‐Based Molecules that Target Bacterial Glucosyltransferase (ChemMedChem 1/2021)
Author(s) -
Hartman Alwin M.,
Jumde Varsha R.,
Elgaher Walid A. M.,
Te Poele Evelien M.,
Dijkhuizen Lubbert,
Hirsch Anna K. H.
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000959
Subject(s) - glucosyltransferase , chemistry , maltose , biofilm , biochemistry , glucan , sugar , combinatorial chemistry , bacteria , enzyme , biology , genetics
The Cover Feature shows the application of dynamic combinatorial chemistry (DCC) for the identification of potential inhibitors of bacterial glucosyltransferase (GTF), a carbohydrate‐modifying enzyme. GTF catalyzes the cleavage of sucrose into fructose and glucose, which can be added to a polysaccharide chain forming α‐glucan, a major component of dental biofilms. Using glucose and maltose‐based aldehydes and various hydrazides, a dynamic library of acylhydrazones was generated. Re‐equilibration in the presence of GTF resulted in amplification of the best binders that could competitively inhibit glucan formation. More information can be found in the Full Paper by Anna K. H. Hirsch et al. Cover design by Walid A. M. Elgaher.