Premium
Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers
Author(s) -
Bergkemper Melanie,
Schepmann Dirk,
Wünsch Bernhard
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000861
Subject(s) - moiety , chemistry , amide , linker , chloroacetyl chloride , benzofuran , alkyl , tetrahydroisoquinoline , stereochemistry , acylation , amine gas treating , combinatorial chemistry , chloride , organic chemistry , computer science , catalysis , operating system
Abstract With the aim to develop new σ 2 receptor ligands, spirocyclic piperidines or cyclohexanamines with 2‐benzopyran and 2‐benzofuran scaffolds were connected to the 6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinoline moiety by variable linkers. In addition to flexible alkyl chains, linkers containing an amide as functional group were synthesized. The 2‐benzopyran and 2‐benzofuran scaffold of the spirocyclic compounds were synthesized from 2‐bromobenzaldehyde. The amide linkers were constructed by acylation of amines with chloroacetyl chloride and subsequent nucleophilic substitution, the alkyl linkers were obtained by LiAlH 4 reduction of the corresponding amides. For the development of σ 2 receptor ligands, the spirocyclic 2‐benzopyran scaffold is more favorable than the ring‐contracted 2‐benzofuran system. Compounds bearing an alkyl chain as linker generally show higher σ affinity than acyl linkers containing an amide as functional group. A higher σ 1 affinity for the cis ‐configured cyclohexanamines than for the trans ‐configured derivatives was found. The highest σ 2 affinity was observed for cis ‐configured spiro[[2]benzopyran‐1,1′‐cyclohexan]‐4′‐amine connected to the tetrahydroisoquinoline system by an ethylene spacer ( cis ‐ 31 , K i (σ 2 )=200 nM; the highest σ 1 affinity was recorded for the corresponding 2‐benzofuran derivative with a CH 2 C=O linker ( cis ‐ 29 , K i (σ 1 )=129 nM).