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Coinage Metal N‐ Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications
Author(s) -
Nayak Swarnagowri,
Gaonkar Santosh L.
Publication year - 2021
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000836
Subject(s) - carbene , combinatorial chemistry , chemistry , drug discovery , nanotechnology , cisplatin , metal , organic chemistry , materials science , biology , catalysis , biochemistry , chemotherapy , genetics
New weapons are constantly needed in the fight against cancer. The discovery of cisplatin as an anticancer drug prompted the search for new metal complexes. The successful history of cisplatin motivated chemists to develop a plethora of metal‐based molecules. Among them, metal‐ N‐ heterocyclic carbene (NHC) complexes have gained significant attention because of their suitable qualities for efficient drug design. The enhanced applications of coinage metal‐NHC complexes have encouraged a gradually increasing number of studies in the fields of medicinal chemistry that benefit from the fascinating chemical properties of these complexes. This review aims to present recent developments in synthetic strategies and medicinal applications of copper, silver and gold complexes supported by NHC ligands.