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Front Cover: Druggability Assessment for Selected Serine Proteases in a Pharmaceutical Industry Setting (ChemMedChem 21/2020)
Author(s) -
Wehrhan Leon,
Hillisch Alexander,
Mundt Stefan,
Tersteegen Adrian,
Meier Katharina
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000798
Subject(s) - druggability , front cover , drug discovery , computational biology , serine protease , proteases , serine , reticle , chemistry , protease , computer science , cover (algebra) , nanotechnology , biochemistry , biology , enzyme , engineering , materials science , mechanical engineering , wafer , gene
The Front Cover shows the backbone representation of a protein structural ensemble for the serine protease FXa with a reticle pointing at it. The potential of targeting a protein with a drug‐like molecule plays an important role in early drug discovery. In their study, the authors address the topic of target druggability assessment. They present key insights from high‐throughput screening (HTS) and protein structure‐based druggability assessments and illustrate that conformational variability matters. More information can be found in the Full Paper by Leon Wehrhan, Katharina Meier et al.