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Benzylaminoethylureido‐Tailed Benzenesulfonamides Show Potent Inhibitory Activity against Bacterial Carbonic Anhydrases
Author(s) -
Ali Majid,
Angeli Andrea,
Bozdag Murat,
Carta Fabrizio,
Capasso Clemente,
Farooq Umar,
Supuran Claudiu T.
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000680
Subject(s) - antibiotics , bacteria , microbiology and biotechnology , enzyme , vibrio cholerae , burkholderia , chemistry , inhibitory postsynaptic potential , biology , biochemistry , genetics , neuroscience
A series of benzylaminoethylureido‐tailed benzenesulfonamides was analyzed for their inhibition potential against bacterial carbonic anhydrases (CAs) such as VhCA α, β, and γ from Vibrio cholerae , and BpsCA β and γ‐CAs from Burkholderia pseudomallei . Growing drug resistance against antibiotics demands alternative targets and mechanisms of action. As CA is essential for the survival of bacteria, such enzymes have the potential for developing new antibiotics. Most of the compounds presented excellent inhibition potential against VhCA γ compared to α and β, with K i values in the range of 82.5–191.4 nM. Several sulfonamides exhibited excellent inhibition against BpsCA β with K i values in the range of 394–742.8 nM. Recently it has been demonstrated that sufonamide CA inhibitors are effective against vancomycin‐resistant enterococci. These data show that CA inhibition of pathogenic bacteria may lead to a new class of antibiotics.