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Advancements in the Development of Non‐Nitrogen‐Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance
Author(s) -
Carden Robert G.,
Sommers Kyle J.,
Schrank Cassandra L.,
Leitgeb Austin J.,
Feliciano Javier A.,
Wuest William M.,
Minbiole Kevin P. C.
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000612
Subject(s) - sulfonium , amphiphile , bacteria , biocide , antibiotic resistance , ammonium , microbiology and biotechnology , phosphonium , chemistry , biology , organic chemistry , salt (chemistry) , genetics , copolymer , polymer
The prevalence of quaternary ammonium compounds (QACs) as common disinfecting agents for the past century has led bacteria to develop resistance to such compounds. Given the alarming increase in resistant strains, new strategies are required to combat this rise in resistance. Recent efforts to probe and combat bacterial resistance have focused on studies of multiQACs. Relatively unexplored, however, have been changes to the primary atom bearing positive charge in these antiseptics. Here we review the current state of the field of both phosphonium and sulfonium amphiphilic antiseptics, both of which hold promise as novel means to address bacterial resistance.