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Gold‐Nanoparticle‐Decorated Metal‐Organic Frameworks for Anticancer Therapy
Author(s) -
Dhakshinamoorthy Amarajothi,
Navalón Sergio,
Asiri Abdullah M.,
Garcia Hermenegildo
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000562
Subject(s) - nanomedicine , nanotechnology , photosensitizer , metal organic framework , nanoparticle , materials science , drug delivery , photodynamic therapy , colloidal gold , catalysis , porosity , chemistry , organic chemistry , adsorption , composite material
Confinement of Au nanoparticles (NPs) within the porous materials with few nanometers (2‐3 nm) has been a well established research area in the past decades in heterogeneous catalysis mainly due to the unique behaviour of Au NPs than its bulk counterpart. In this aspect, Au NPs encapsulated within the pore volumes of metal−organic frameworks (MOFs) have been intensively explored as heterogeneous solid catalysts for wide range of reactions. In recent years, Au NPs confined within the porous MOFs along with the photosensitizer or drug have been effectively used for the treatment of tumor cells through the generation of reactive oxygen species via cascade reactions. This work highlights the benefits of MOFs pores in the preparation of nanomedicine with high efficiency by assembling Au NPs, photosensitizer/drug with the combination of laser either for imaging or treatment of tumor cells. Further, the existing literature is grouped based on the nature of porous materials employed in the preparation of nanomedicine. The final section comments on our view on future developments in the field.