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Front Cover: Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate‐Based Inhibitors of Cytochrome bo 3 Ubiquinol Oxidase from Escherichia coli (ChemMedChem 14/2020)
Author(s) -
Elamri Isam,
Radloff Melanie,
Hohmann Katharina F.,
Nimbarte Vijaykumar D.,
Nasiri Hamid R.,
Bolte Michael,
Safarian Schara,
Michel Hartmut,
Schwalbe Harald
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000481
Subject(s) - ubiquinol , escherichia coli , cytochrome , chemistry , oxidase test , substrate (aquarium) , front cover , stereochemistry , cytochrome c , combinatorial chemistry , coenzyme q – cytochrome c reductase , biochemistry , cover (algebra) , enzyme , biology , mitochondrion , gene , ecology , mechanical engineering , engineering
The Front Cover shows that it′s not enough to just win—you also need to be precise in doing so. The precise bowling here represents the selective inhibitory effect of new alkylated Lawson derivatives on cytochrome bo 3 oxidase (cyt bo 3 ) without affecting cytochrome bd‐I activity, even though i n Escherichia coli, both respiratory terminal oxidases use ubiquinol‐8 as electron donor. More information can be found in the Full Paper by Harald Schwalbe et al.