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Front Cover: Synthetic Peroxides Promote Apoptosis of Cancer Cells by Inhibiting P‐Glycoprotein ABCB5 (ChemMedChem 13/2020)
Author(s) -
Yaremenko Ivan A.,
Coghi Paolo,
Prommana Parichat,
Qiu Congling,
Radulov Peter S.,
Qu Yuanqing,
Belyakova Yulia Yu.,
Zanforlin Enrico,
Kokorekin Vladimir A.,
Wu Yuki Yu Jun,
Fleury Fabrice,
Uthaipibull Chairat,
Wong Vincent Kam Wai,
Terent'ev Alexander O.
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000413
Subject(s) - p glycoprotein , cancer cell , apoptosis , efflux , multiple drug resistance , front cover , chemistry , cytotoxicity , transporter , cancer , cancer research , biochemistry , cover (algebra) , biology , in vitro , gene , genetics , mechanical engineering , engineering , antibiotics
The Front Cover shows the effort of three collaborators from Thailand (BIOTEC), Macau (MUST), and Russia (Zelinsky Institute of Organic Chemistry RAS) on the discovery of promising anticancer agents based on synthetic peroxides. Multidrug resistance (MDR) driven by the overexpression of ATP‐binding cassette (ABC) transporters in cancer cells is a serious problem which hampers the success of cancer chemotherapy. Synthetic peroxides demonstrate high cytotoxicity and selectivity against liver cancer cells. They promote apoptosis of cancer cells and exhibit inhibitory effect on P‐glycoprotein (P‐gp/ABCB5) efflux transporter. More information can be found in the Full Paper by Vincent Kam Wai Wong, Chairat Uthaipibull, Alexander O. Terent′ev et al.