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Front Cover: Binding and Release of FeIII Complexes from Glucan Particles for the Delivery of T 1 MRI Contrast Agents (ChemMedChem 12/2020)
Author(s) -
Patel Akanksha,
Asik Didar,
Snyder Eric M.,
Dilillo Alexandra E.,
Cullen Paul J.,
Morrow Janet R.
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000366
Subject(s) - paramagnetism , mri contrast agent , cover (algebra) , front cover , magnetic resonance imaging , chemistry , proton , chelation , nuclear magnetic resonance , contrast (vision) , crystallography , medicine , physics , inorganic chemistry , radiology , mechanical engineering , engineering , optics , quantum mechanics
The Front Cover shows yeast‐derived β‐glucan particles (GPs) loaded with a paramagnetic, high spin iron(III) coordination complex. The iron(III) complex is under development as a magnetic resonance imaging (MRI) contrast agent. The complex remains encapsulated in GPs under physiological conditions, and its water proton relaxivity is masked. Addition of the maltol chelator or mild acid releases the iron(III) complex from the GPs to restore the proton relaxivity of the complex as an MRI contrast agent. The cover art was inspired by Vincent van Gogh′s Starry Night. More information can be found in the Full Paper by Janet R. Morrow et al.