Premium
Synthesis of N‐Aryl‐ and N‐alkyl‐Substituted Imidazolium Silver Complexes: Cytotoxic Screening by Using Human Cell Lines Modelling Acute Myeloid Leukaemia
Author(s) -
Alme Eirin,
Törnroos Karl Wilhelm,
Gjertsen Bjørn Tore,
Bjørsvik HansRené
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000138
Subject(s) - alkyl , cytotoxicity , aryl , imidazole , chemistry , cell culture , cytotoxic t cell , in vitro , stereochemistry , medicinal chemistry , organic chemistry , biology , biochemistry , genetics
A series of N‐aryl‐ and N‐alkyl substituted imidazoles has been synthesised and complexed with Ag + to obtain silver‐NHC complexes of the form [Ag(NHC) 2 ]X. These silver‐NHC complexes were tested in vitro against the human cell lines HL‐60 and MOLM‐13, which both model acute myeloid leukaemia (AML). A substantial difference in cytotoxicity was revealed varying in the range 13–4 μM and 22–9 μM for HL‐60 and MOLM‐13, respectively. Furthermore, this study revealed that when an alkyl group is installed on the imidazole scaffold, its position substantially influences the cytotoxicity of the corresponding silver NHC complex.