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Sulfated and Oxygenated Imidazoline Derivatives: Synthesis, Antioxidant Activity and Light‐Mediated Antibacterial Activity
Author(s) -
Faillace Martín S.,
Silva Ana P.,
Alves Borges Leal Antonio L.,
Muratori da Costa Luciana,
Barreto Humberto M.,
Peláez Walter J.
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000048
Subject(s) - chemistry , antioxidant , imidazoline receptor , antibacterial activity , abts , dpph , sulfation , staphylococcus aureus , escherichia coli , combinatorial chemistry , organic chemistry , biochemistry , bacteria , pharmacology , biology , genetics , gene
Imidazoline derivatives with different exocyclic substituents were simply prepared from common starting materials. The procedures were carried out in an eco‐friendly manner. The antioxidant activity of these derivatives was explored by different experimental assays, such as ABTS .+ and DPPH . scavenging assay, as well as reducing power assay. The structural differences are discussed in terms of the results. Sulfur analogs showed higher antioxidant activity than their oxygenated counterparts. The same tendency was observed in microbiological studies, in which the same imidazoline compounds were assayed for light‐mediated activity against of Staphylococcus aureus and Escherichia coli strains. A light‐enhanced activity was observed for almost all the sulfated imidazolines after exposure to UV‐A (400‐320 nm) light.