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Cover Feature: Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity (ChemMedChem 3/2020)
Author(s) -
Fois Benedetta,
Skok Žiga,
Tomašič Tihomir,
Ilaš Janez,
Zidar Nace,
Zega Anamarija,
Peterlin Mašič Lucija,
Szili Petra,
Draskovits Gábor,
Nyerges Ákos,
Pál Csaba,
Kikelj Danijel
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202000031
Subject(s) - dna gyrase , escherichia coli , antibacterial activity , cover (algebra) , chemistry , ciprofloxacin , protein subunit , dna , bacteria , microbiology and biotechnology , computational biology , combinatorial chemistry , biology , genetics , gene , biochemistry , engineering , mechanical engineering
The Cover Feature shows a representative DNA gyrase B (GyrB) inhibitor/ciprofloxacin hybrid that penetrates into Escherichia coli and displays antibacterial activity. The observed antibacterial activity of these hybrid molecules is mainly due to interaction with GyrA and/or ParC and not with the GyrB subunit, because inhibition of GyrB by the presented hybrids, although present, is not strong enough to provide a substantial contribution to the observed antibacterial activity. More information can be found in the Communication by Danijel Kikelj et al. on page 265 in Issue 3, 2020 (DOI: 10.1002/cmdc.201900607).