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Metal‐Organic Sheets for Efficient Drug Delivery and Bioimaging
Author(s) -
Song Yucong,
Yang Jingjie,
Wang Lei,
Xie Zhigang
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201900664
Subject(s) - biocompatibility , nanotechnology , metal organic framework , drug delivery , nanoscopic scale , metal ions in aqueous solution , metal , materials science , doxorubicin , chemistry , combinatorial chemistry , nanoparticle , organic chemistry , adsorption , medicine , surgery , chemotherapy
Abstract Metal‐organic frameworks (MOFs) formed by coordination between metal ions or clusters and organic bridging ligands possess great potential for biomedicine applications, given their high biocompatibility and biodegradability. Compared with the traditional three‐dimensional (3D) MOFs, two‐dimensional (2D) MOFs with sheet‐like morphologies exhibit unique properties. In this study, a nanoscale 2D leaf‐shaped MOF (NZIF−L) was synthesized via coordination self‐assembly between 2‐methylimidazole (Hmim) and Zn 2+ with subsequent morphology and size control. The fabricated NZIF−L is cytocompatible and can be quickly endocytosed, which makes it an excellent cargo carrier. Subsequent to loading with either doxorubicin (DOX) or 4,4′‐(1,2‐diphenylvinyl)‐1,2‐di‐(phenylcarboxylic acid) (TCPE), the respectively obtained DOX@NZIF−L and TCPE@NZIF−L showed promise for killing and imaging cancer cells.