A Flexible Strategy for Modular Synthesis of Curcuminoid‐BF 2 /Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines | Zendy

Abonia Rodrigo | Zendy; Laali Kenneth K. | Zendy; Raja Somu Dawn | Zendy; Bunge Scott D. | Zendy; Wang Esther C. | Zendy

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A Flexible Strategy for Modular Synthesis of Curcuminoid‐BF 2 /Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines

Author(s) -

Abonia Rodrigo,

Laali Kenneth K.,

Raja Somu Dawn,

Bunge Scott D.,

Wang Esther C.

Publication year - 2020

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201900640

Subject(s) - curcuminoid , curcumin , cancer cell lines , stereochemistry , chemistry , combinatorial chemistry , modular design , cell culture , scope (computer science) , cancer cell , cancer , nanotechnology , biochemistry , biology , computer science , genetics , materials science , operating system , programming language

A facile protocol that enables synthetic interconversion of CUR‐BF 2 and CUR compounds is described that significantly widens the preparative scope of curcuminoids, providing access to larger libraries of compounds, thus enabling comparative antiproliferative and apoptotic study of a larger library of synthetic analogs in cancer cell lines.

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