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A Flexible Strategy for Modular Synthesis of Curcuminoid‐BF 2 /Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines
Author(s) -
Abonia Rodrigo,
Laali Kenneth K.,
Raja Somu Dawn,
Bunge Scott D.,
Wang Esther C.
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201900640
Subject(s) - curcuminoid , curcumin , cancer cell lines , stereochemistry , chemistry , combinatorial chemistry , modular design , cell culture , scope (computer science) , cancer cell , cancer , nanotechnology , biochemistry , biology , computer science , genetics , materials science , operating system , programming language
A facile protocol that enables synthetic interconversion of CUR‐BF 2 and CUR compounds is described that significantly widens the preparative scope of curcuminoids, providing access to larger libraries of compounds, thus enabling comparative antiproliferative and apoptotic study of a larger library of synthetic analogs in cancer cell lines.