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Hypocrellin Derivative‐Loaded Calcium Phosphate Nanorods as NIR Light‐Triggered Phototheranostic Agents with Enhanced Tumor Accumulation for Cancer Therapy
Author(s) -
Wang Hongyi,
Jia Qingyan,
Liu Weimin,
Nan Fuchun,
Zheng Xiuli,
Ding Ying,
Ren Haohui,
Wu Jiasheng,
Ge Jiechao
Publication year - 2020
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201900512
Subject(s) - nanorod , photodynamic therapy , in vivo , fluorescence , absorption (acoustics) , chemistry , phosphate , in vitro , nuclear chemistry , near infrared spectroscopy , calcium , materials science , nanotechnology , biochemistry , organic chemistry , optics , physics , microbiology and biotechnology , composite material , biology
Dopamine modified hypocrellin B (DAHB) derivative‐loaded calcium phosphate nanorods (DAHB@CaP NRs) were prepared as a novel phototheranostic agent for effective tumor imaging and therapy. DAHB@CaP NRs were obtained through microwave treatment using DAHB, CaCl 2 , NH 3 ⋅H 2 O, and H 3 PO 4 as precursors. The DAHB@CaP NRs possessed the following advantages: 1) efficient absorption in the near‐infrared (NIR) region from 650 nm to 800 nm; 2) maximum NIR emission at approximately 735 nm; 3) enhanced cellular uptake efficiency in vitro and in vivo ; and 4) efficient inhibition of tumor growth and low biotoxicity. These properties indicate the high capability of DAHB@CaP NRs for NIR fluorescence (FL) imaging‐guided photodynamic therapy of cancer, thus offering promising new prospects for clinical applications.