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Front Cover: Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies (ChemMedChem 17/2019)
Author(s) -
Bartholomäus Ruben,
Nicolussi Simon,
Baumann Alice,
Rau Mark,
Simão Ana Catarina,
Gertsch Jürg,
Altmann KarlHeinz
Publication year - 2019
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201900490
Subject(s) - front cover , pepper , natural product , chemistry , endocannabinoid system , cover (algebra) , total synthesis , stereochemistry , biochemistry , food science , engineering , mechanical engineering , receptor
The Front Cover shows Guineensine in the foreground, a natural product derived from the fruits of black pepper, Piper nigrum , and several other pepper species. Guineensine is a natural uptake inhibitor of endocannabinoids, thereby showing cannabimimetic and also pronounced antiinflammatory effects. The authors devised a total synthesis of Guineensine in five steps. Additionally, they synthesized derivatives of Guineensine for studying structure–activity relationships. Cover picture by Alice Baumann with help from Barth van Rossum (FMP Berlin). Brain picture from Jolygon/shutterstock.com. Background picture of pepper plant from Jürg Gertsch. More information can be found in the Full Paper by Karl‐Heinz Altmann et al. on page 1590 in Issue 17, 2019 (DOI: 10.1002/cmdc.201900390).