Premium
Cover Feature: Discovery of Small‐Molecule Antibiotics against a Unique tRNA‐Mediated Regulation of Transcription in Gram‐Positive Bacteria (ChemMedChem 7/2019)
Author(s) -
Frohlich Kyla M.,
Weintraub Spencer F.,
Bell Janeen T.,
Todd Gabrielle C.,
Väre Ville Y. P.,
Schneider Ryan,
Kloos Zachary A.,
Tabe Ebot S.,
Cantara William A.,
Stark Caren J.,
Onwuanaibe Urenna J.,
Duffy Bryan C.,
BasantaSanchez Maria,
Kitchen Douglas B.,
McDonough Kathleen A.,
Agris Paul F.
Publication year - 2019
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201900178
Subject(s) - transfer rna , transcription (linguistics) , in silico , rna , riboswitch , biology , computational biology , bacteria , untranslated region , small molecule , chemistry , genetics , biochemistry , gene , non coding rna , linguistics , philosophy
The Cover Feature shows 20 of 200 compounds that were bound strongly in silico within an RNA grove. The 200 compounds were selected from 305,000. They were used to target an RNA function, the tRNA‐dependent regulatory mechanism unique to Gram‐positive pathogens, in search of a novel compound that inhibits bacterial growth and reduces emergent resistance. The green RNA helix (top and bottom) is part of Stem 1 of the 5’‐untranslated region of nascent mRNAs, the transcription of which is regulated by unacylated tRNA. The blue is a loop that consists of an adenosine‐rich stack and a red “codon” that binds the tRNA anticodon. More information can be found in the Full Paper by Paul F. Agris et al. on page 758 in Issue 7, 2019 (DOI: 10.1002/cmdc.201800744).