Premium
Front Cover: Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)‐Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei (ChemMedChem 6/2019)
Author(s) -
Cerone Michela,
Uliassi Elisa,
Prati Federica,
Ebiloma Godwin U.,
Lemgruber Leandro,
Bergamini Christian,
Watson David G.,
de A. M. Ferreira Thais,
Roth Cardoso Gabriella Simões Heyn,
Soares Romeiro Luiz A.,
de Koning Harry P.,
Bolognesi Maria Laura
Publication year - 2019
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201900135
Subject(s) - cashew nut , neglected tropical diseases , drug discovery , microbiology and biotechnology , trypanosoma brucei , tropical disease , biology , disease , medicine , agricultural science , bioinformatics , biochemistry , gene , pathology
The Front Cover shows an entire research pathway (from laboratory bench to patient bedside) of a drug discovery approach aimed to develop sustainable drugs for a poverty‐related disease, i.e. African Trypanosomiasis (HAT). Particularly, it explores the possibility of obtaining hybrid small molecules, with the potential to be used as more accessible antiparasitic drugs, from food factory wastes. The fact that the food waste used as raw material is cashew nut shell liquid (CNSL) hints at a potential key role of endemic tropical countries, which are the largest CNSL‐producers, in the development of new drugs for HAT. More information can be found in the Full Paper by Maria Laura Bolognesi et al. on page 621 in Issue 6, 2019 (DOI: 10.1002/cmdc.201800790).