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Cover Feature: Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies (ChemMedChem 5/2019)
Author(s) -
Ghosh Arun K.,
Brindisi Margherita,
Yen YuChen,
Lendy Emma K.,
Kovela Satish,
Cárdenas Emilio Leal,
Reddy Bhavanam Sekhara,
Rao Kalapala Venketeswara,
Downs Deborah,
Huang Xiangping,
Tang Jordan,
Mesecar Andrew D.
Publication year - 2019
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201900100
Subject(s) - cover (algebra) , statue , feature (linguistics) , chemistry , stereochemistry , art history , art , philosophy , engineering , mechanical engineering , linguistics
The Cover Feature shows the X‐ray structure of β‐secretase 1 bound to compound 2a (top). The structure was utilized to create an active model of 2a with β‐secretase 2, which led to the design and synthesis of highly potent and selective β‐secretase 2 inhibitor 2d (CPK green picture, bottom) with potential for a new treatment of type 2 diabetes. A commemorative statue of Purdue graduate, Neil Armstrong, the first human to step on the moon surface (footsteps, bottom right), looks onward at Purdue University. He is forever a symbol of the incredible human spirit that continues to strive for that next great achievement. Cover art created by Anando John Ghosh. More information can be found in the Full Paper by Arun K. Ghosh et al. on page 545 in Issue 5, 2019 (DOI: 10.1002/cmdc.201800725).