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Cover Feature: Evaluation of Sydnone‐Based Analogues of Combretastatin A‐4 Phosphate (CA4P) as Vascular Disrupting Agents for Use in Cancer Therapy (ChemMedChem 24/2018)
Author(s) -
Brown Andrew W.,
Holmes Toby,
Fisher Matthew,
Tozer Gillian M.,
Harrity Joseph P. A.,
Kanthou Chryso
Publication year - 2018
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201800768
Subject(s) - sydnone , chemistry , feature (linguistics) , cover (algebra) , cancer therapy , cancer , cancer cell , combinatorial chemistry , medicine , ring (chemistry) , organic chemistry , mechanical engineering , linguistics , philosophy , engineering
The Cover Feature shows a novel sydnone‐based analog of the combretastatins which target and disrupt microtubules, affecting cellular morphology, even at submicromolar concentrations. These compounds offer a new platform for developing hydrophilic, configurationally stable analogs of combretastatins, and a new arsenal of weapons for the fight against cancer. More information can be found in the Full Paper by Gillian M. Tozer, Joseph P. A. Harrity, Chryso Kanthou et al. on page 2618 in Issue 24, 2018 (DOI: 10.1002/cmdc.201800567).