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The Role of the Phosphorus Atom in Drug Design
Author(s) -
Rodriguez Juan B.,
GalloRodriguez Carola
Publication year - 2019
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201800693
Subject(s) - phosphinate , phosphonate , phosphorus , prodrug , phosphate , chemistry , nucleotide , functional group , molecule , drug , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , pharmacology , biology , gene , fire retardant , polymer
Although the phosphorus atom is found in a variety of oxidation states, most of the phosphorus‐containing molecules of pharmacological importance possess phosphorus in the form of phosphonate or phosphinate functional groups, or in a major oxidation state as a phosphate group. The most common occurrence of phosphorus in drugs is either in prodrugs or in compounds for which the phosphorus atom plays a role in the biological activity, such as in modified nucleotides, in metabolically stable analogues of metabolites bearing phosphate groups, and as bioisosteric analogues of carboxyl groups.