Premium
Front Cover: Employing Photoredox Catalysis for DNA‐Encoded Chemistry: Decarboxylative Alkylation of α‐Amino Acids (ChemMedChem 20/2018)
Author(s) -
Kölmel Dominik K.,
Loach Richard P.,
Knauber Thomas,
Flanagan Mark E.
Publication year - 2018
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201800645
Subject(s) - chemistry , radical , front cover , iridium , photoredox catalysis , dna , catalysis , alkylation , combinatorial chemistry , amino acid , posttranslational modification , photochemistry , aqueous solution , photocatalysis , cover (algebra) , organic chemistry , biochemistry , enzyme , mechanical engineering , engineering
The Front Cover shows a 96‐well blue LED array which can be used for the photoredox‐mediated functionalization of DNA‐tagged substrates in aqueous media. More specifically, an iridium‐based photocatalyst (shown above the reaction arrow) induces decarboxylative radical formation from readily available α‐amino acids. Those C‐centered radicals can subsequently add to various DNA‐tagged radical acceptors to forge a new C(sp 3 )‐C(sp 3 ) bond. Due to the mild and DNA‐compatible reaction conditions, this Giese‐type coupling is of particular interest for the preparation of future DNA‐encoded libraries. More information can be found in the Communication by Mark E. Flanagan et al. on page 2159 in Issue 20, 2018 (DOI: 10.1002/cmdc.201800492).