Cover Feature: Structural Mapping of Anion Inhibitors to β‐Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa (ChemMedChem 19/2018)

The Cover Feature illustrates the crystal structure of dimeric β‐carbonic anhydrase, psCA3, found in Pseudomonas aeruginosa . This multidrug‐resistant bacterium commonly causes life‐threatening nosocomial infections and is a key bacterial agent in cystic fibrosis patients. Therefore, discovering novel drug targets against this bacterium is critical. As carbonic anhydrases are necessary for growth and function of Pseudomonas aeruginosa , they can be targeted for antibiotic development. This work shows the first inhibitor structures bound to psCA3 and is fundamental in establishing structure‐based drug design against Pseudomonas aeruginosa . More information can be found in the Full Paper by Robert McKenna et al. on page 2024 in Issue 19, 2018 (DOI: 10.1002/cmdc.201800375).