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Ectonucleotidase Inhibitory and Redox Activity of Imidazole‐Based Organic Salts and Ionic Liquids
Author(s) -
Boldescu Veaceslav,
Sucman Natalia,
Hassan Sidra,
Iqbal Jamshed,
Neamtu Mariana,
Lecka Joanna,
Sévigny Jean,
Prodius Denis,
Macaev Fliur
Publication year - 2018
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201800520
Subject(s) - chemistry , cytotoxicity , imidazole , aldehyde , hela , redox , singlet oxygen , ionic liquid , medicinal chemistry , oxygen , combinatorial chemistry , organic chemistry , biochemistry , cell , in vitro , catalysis
Cytotoxicity against cancer and normal cells, inhibition of ectonucleotidase, and redox properties of a new group of imidazole‐based organic salts and ionic liquids were studied. The tetrachloroferrate salt of a 1‐methylimidazole derivative of salicylic aldehyde had most prominent inhibitory activity against ectonucleotidase as well as a higher cytotoxicity against HeLa cells and lower cytotoxicity against BHK‐21 cells than the reference compound carboplatin. The studied compounds exhibited a moderate level of antioxidant activity with better results for the salicylic aldehyde derivatives than for spiropyrans. Moreover, these compounds did not generate singlet oxygen.